Stem Cells at the National Academies

Emerging Issues in Human Embryonic Stem Cell Research
Public Symposium

November 7-8, 2006
National Academy of Sciences
2100 C Street, N.W.
Washington, D.C.

DAY 1 - TUESDAY, NOVEMBER 7, 2006

8:00	Continental Breakfast, Great Hall, National Academy of Sciences

8:30	Introduction and Welcome R. Alta Charo, Co-Chair, Human Embryonic Stem Cell Research Advisory Committee; Warren P. Knowles Professor of Law & Bioethics, University of Wisconsin-Madison; Visiting Professor of Law, University of California, Berkeley Boalt Hall School of Law Richard O. Hynes, Co-Chair, Human Embryonic Stem Cell Research Advisory Committee; Daniel K. Ludwig Professor for Cancer Research, Massachusetts Institute of Technology; Investigator, Howard Hughes Medical Institute
8:40	The Intersection between Emerging Areas of hES Cell Research and the NAS Guidelines Richard O. Hynes, Co-Chair, Human Embryonic Stem Cell Research Advisory Committee; Daniel K. Ludwig Professor for Cancer Research, Massachusetts Institute of Technology; Investigator, Howard Hughes Medical Institute Download Presentation Slides \| Audio Clip


SESSION I: hES CELL DERIVATION AND PROCUREMENT

The Use of Oocytes in hES Cell Research Richard O. Hynes, Panel Chair, Co-Chair, Human Embryonic Stem Cell Research Advisory Committee; Daniel K. Ludwig Professor for Cancer Research, Massachusetts Institute of Technology; Investigator, Howard Hughes Medical Institute
8:55	SCNT: New and Anticipated Scientific Advances Kevin Eggan, Assistant Professor of Molecular and Cellular Biology, Harvard University Download Presentation Slides \| Audio Clip
9:15	Oocyte Procurement, Safety, and Use: Overview of the National Academies Workshop on the Medical Risks of Human Oocyte Donation for Stem Cell Research [by videoconference] Linda C. Giudice, Chair, National Academies Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research; Robert B. Jaffe, MD, Endowed Chair in the Reproductive Sciences; Department of Obstetrics, Gynecology and Reproductive Sciences; University of California, San Francisco Download Presentation Slides \| Audio Clip
9:35	Cellular and Molecular Mechanisms Governing In-vitro Maturation of Oocytes and Other Sources of Oocytes Shehua Shen, Director of Embryology Laboratory, Center for Reproductive Health; Assistant Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco Download Presentation Slides \| Audio Clip
9:55	Perspectives on the Ethics of Egg Donation Insoo Hyun, Assistant Professor of Bioethics, Case Western Reserve University Download Presentation Slides \| Audio Clip

10:15	BREAK

The Use of Embryos in hES Cell Research Ron McKay, Panel Chair, Senior Investigator, Laboratory of Molecular Biology, National Institute of Neurological Disease and Stroke, National Institutes of Health,
10:30	Human Embryonic Stem Cell Lines Derived from Single Blastomeres Robert Lanza, Vice President of Research and Scientific Development, Advanced Cell Technology Download Presentation Slides \| Audio Clip
10:50	Alternative Methods for Deriving "Embryonic Stem Cells": Induction of Pluripotency in Somatic Cells Shinya Yamanaka, Professor, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan Download Presentation Slides \| Audio Clip
11:10	Alternative Methods for Deriving "Embryonic Stem Cells": Germ Cells Renee Reijo Pera, Associate Professor; Departments of Obstetrics, Gynecology & Reproductive Sciences; Physiology; and Urology; University of California, San Francisco Download Presentation Slides \| Audio Clip
11:30	Other Alternative Methods for Deriving "Embryonic Stem Cells" Ron McKay, Senior Investigator, Laboratory of Molecular Biology, National Institute of Neurological Disease and Stroke, National Institutes of Health Download Presentation Slides \| Audio Clip
11:50	Panel Discussion: Alternative Methods for Deriving "Embryonic Stem Cells": Religious, Ethical, and Legal Considerations Suzanne Holland, Associate Professor of Ethics and Chair, Department of Religion, University of Puget Sound Audio Clip Henry T. Greely, Deane F. and Kate Edelman Johnson Professor of Law; Professor, by courtesy, of Genetics; Stanford University Download Presentation Outline \| Audio Clip

12:30	LUNCH


SESSION II: DIRECTED DIFFERENTIATION AND USE OF EMBRYONIC STEM CELLS

Overview of New and Anticipated Advances in the Differentiation of Stem Cells Alan Colman, Panel Chair, Chief Executive Officer, ES Cell International; Senior Scientist, ASTAR Centre for Molecular Medicine, Singapore*
1:30	Directed Differentiation and Use of Embryonic Stem Cells: Pancreatic Cells Alan Colman, Chief Executive Officer, ES Cell International; Senior Scientist, ASTAR Centre for Molecular Medicine, Singapore* Download Presentation Slides \| Audio Clip
1:50	Cellular and Molecular Mechanisms Governing the Self-Renewal and Differentiation of Embryonic Stem Cells: Neuronal Cells Lorenz Studer, Associate Member, Sloan-Kettering Institute and Memorial Sloan-Kettering Cancer Center Audio Clip
2:10	Transformation of Lineages in Fetal and Adult Stem Cells Amy Wagers, Investigator, Joslin Diabetes Center; Assistant Professor of Pathology, Harvard Medical School Download Presentation Slides \| Audio Clip
2:40	Discussion

2:55	BREAK

Chimeras Terry Magnuson, Panel Chair, Member, Human Embryonic Stem Cell Research Advisory Committee; Sarah Graham Kenan Professor and Chair, Department of Genetics; Director, Carolina Center for Genome Sciences; University of North Carolina at Chapel Hill
3:25	Chimeras: New and Anticipated Scientific Advances Clive N. Svendsen, Professor, Anatomy and Neurology, Waisman Center, University of Wisconsin-Madison Download Presentation Slides \| Audio Clip
3:55	Ethical Considerations for Chimera Research Robert Streiffer, Associate Professor of Philosophy and Bioethics, University of Wisconsin-Madison Download Presentation Slides \| Audio Clip Henry T. Greely, Deane F. and Kate Edelman Johnson Professor of Law; Professor, by courtesy, of genetics;Stanford University Download Presentation Outline \| Audio Clip


SESSION III: OPEN FORUM

4:25	General Discussion Moderator: Richard O. Hynes
5:15	ADJOURN TO RECEPTION Great Hall, National Academy of Sciences





DAY 2 - WEDNESDAY, NOVEMBER 8, 2006


8:00	Continental Breakfast, Great Hall, National Academy of Sciences


SESSION IV: IMPLEMENTATION OF RESEARCH GUIDELINES AND REGULATION OF hES CELL RESEARCH Audio Clip: Listen to Day 2 of the Symposium

8:30	Introduction to Session R. Alta Charo, Session Chair, Co-Chair, Human Embryonic Stem Cell Research Advisory Committee; Warren P. Knowles Professor of Law & Bioethics, University of Wisconsin-Madison; Visiting Professor of Law, University of California, Berkeley Boalt Hall School of Law
8:45	Feedback on Implementation of 2005 National Academies Guidelines for Human Embryonic Stem Cell Research: Panel of ESCRO committee chairs and other stakeholders Among the questions to be addressed: What is the structure and composition of your ESCRO committee? Is this adequate? What impediments have you faced in developing your ESCRO committee? Are changes needed to the Guidelines to help facilitate the establishment of an ESCRO committee? Are changes needed to the Guidelines to help facilitate the decisions made by an ESCRO committee? What have been some of the positive and negative experiences associated with your work on your ESCRO committee, which could be affected by the Guidelines? Panelists: Leona Brenner-Gati, Vice-chair, ESCRO Committee; Vice President of Science & Technology; Johnson & Johnson Download Presentation Slides Jeffrey Jones, Director of Research Services, WiCell Research Institute; University of Wisconsin-Madison ESCRO Committee Jane Lebkowski, Senior Vice President of Tissue Regenerative Medicine, Geron Corporation Bernard Lo, Professor of Medicine; Director, Program in Medical Ethics; Chair, ESCRO Committee; University of California, San Francisco Download Presentation Slides Alan Meisel, Director, Center for Bioethics and Health Law; Dickie, McCamey & Chilcote Professor of Ethics, and Professor of Law and Psychiatry; Chair, ESCRO Committee; University of Pittsburgh Download Presentation Slides Ralph Nachman, E. Hugh Luckey Distinguished Professor and Chair, Department of Medicine, Weill Medical College, Cornell University; Chair, Tri-Institutional ESCRO Committee (Rockefeller University, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University) P. Pearl O'Rourke, Director, Human Research Affairs; Chair, ESCRO Committee; Partners HealthCare System, Boston; Associate Professor of Medicine, Harvard Medical School

10:45	BREAK

11:00	Open Discussion Moderator: R. Alta Charo

12:00	ADJOURN

2006 Symposium