Study in Progress

Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions

Meetings

Design and Evaluation of Safer Chemical Substitutions ? A Framework to Inform Government and Industry Decisions - 02/06/14
Chemical Substitutions Meeting 4 - 05/08/14

Statement of Task

An ad hoc committee will develop a decision framework for evaluating potential safer substitute chemicals as determined by human health and ecological risks. The committee will identify the scientific information and tools required by regulatory agencies and industry to improve and increase consideration of potential health and environmental impacts early in the chemical design process. The decision framework will be capable of integrating multiple and diverse data streams to support early consideration of potential health and environmental impacts as a part of fit-for-purpose decision making. The framework will discuss how risk (hazard and potential for human exposure and toxicity) and environmental impact (ecological risks) can be characterized for chemical substitutions within the context of the full range of benefits and shortcomings of substitutes, and how tradeoffs between these risks and factors such as product functionality, product efficacy, process safety and resource use can be quantified. In its report, the committee will describe the framework and provide at least two examples that demonstrate how the framework can be applied by different users in contrasting decision contests with diverse priorities. These examples will include demonstration of how high throughput and high content data streams could inform assessment of potentially safer substitutes early in the chemical development process.