Toxic Chemicals, Toxicity Testing: Consensus Reports

The division produces 60-70 reports per year. These reports are unique, authoritative expert evaluations. Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review. The experts who volunteer their time participating on study committees are vetted to make sure that the committee has the range of expertise needed to address the task, that they have a balance of perspectives, and to identify and eliminate members with conflicts of interest. All reports undergo a rigorous, independent peer review to assure that the statement of task has been addressed, that conclusions are adequately supported, and that all important issues raised by the reviewers are addressed. Thus, while the reports represent views of the committee, they also are endorsed by the Academy.

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Showing results 1 - 5 of 65

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals (2017)

The U.S. Environmental Protection Agency (EPA) regulates toxic chemicals as part of its mission to protect human health and the environment. Traditional toxicity testing relies heavily on studies that expose test animals to chemicals at amounts much higher than typical human exposures (i.e., low doses). However, some chemicals can cause health effects at low doses. This report outlines a strategy to improve EPA's ability to evaluate evidence o... More >>

Report in Brief

Using 21st Century Science to Improve Risk-Related Evaluations (2017)

The availability of tools to assess human health risks from chemical exposures have increased rapidly in the 21st century. For example, new personal sensors and sampling techniques offer unparalleled opportunities to characterize individual exposures, new in vitro assays can now evaluate a number of cellular processes and responses, and -omics technologies have advanced molecular epidemiology, which focuses on underlying biology rather tha... More >>

Report in Brief

Characterization, Modeling, Monitoring, and Remediation of Fractured Rock (2015)

Characterizing and modeling fluid flow through fractured rock is vital to limiting the spread of chemical contaminants through rock features; for understanding where reservoirs of petroleum, water, or geothermal resources may form; and for engineering stable and resilient underground infrastructure. Over the past twenty years there have been significant advances in abilities to model and characterize these pathways, but significant challenge... More >>

Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens (2014)

In 1981, the National Toxicology Program (NTP) listed formaldehyde in the 2nd Report on Carcinogens (RoC) as "reasonably anticipated to be a human carcinogen." In 2011, NTP upgraded the listing of formaldehyde in the 12th RoC to "known to be a human carcinogen." Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences to independently review formaldehyde’s substanc... More >>

Report in Brief

Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens (2014)

In 2011, the National Toxicology Program listed styrene as "reasonably anticipated to be a human carcinogen" in its 12th Report on Carcinogens. Congress directed the Department of Health and Human Services to request the National Academy of Sciences to review independently the substance profile of styrene and its listing in the Report on Carcinogens. This report presents the findings and conclusions of the committee formed in response to th... More >>

Report in Brief