Committee Membership Information

Study Title:

Review of EPA's IRIS Toxicological Assessments of Inorganic Arsenic

Study Director:

Dr. Aaron Barchowsky - (Chair)
University of Pittsburgh

Aaron Barchowsky is professor in the Department of Environmental and Occupational Health at the University of Pittsburgh. His research interests are in investigating the cellular and molecular mechanisms underlying cardiovascular and lung diseases caused by environmental exposures to metals and chronic changes in redox status. In vivo and cell-cultured?based studies focus on the molecular pathology and etiology of vascular and metabolic diseases caused by chronic exposure to low concentrations of arsenic in drinking water. The cell-signaling pathways that mediate arsenic-stimulated pathogenic changes in vascular and perivascular progenitor cells are being investigated. He has also contributed to the World Health Organizations assessment of the global burden of cancer and cardiovascular disease caused by arsenic exposure in food. Dr. Barchowsky is a councilor of the Society of Toxicology, and formerly served as president of the Metals Specialty Section and chair of the Education Committee. He received his PhD in pharmacology from Duke University.

Dr. William C. Griffith
University of Washington

William C. Griffith is a principle scientist and Director of Biostatistics at the Institute for Risk Analysis and Risk Communication in the Department of Environmental and Occupational Health Sciences at the University of Washington. He has expertise in the areas of biostatistics, dosimetric and toxico-kinetic models, radiation toxicology of internally deposited radionuclides, Markov-chain Monte Carlo methods, and semiparametric function estimation. He is currently a member of the US Environmental Protection Agency?s Clean Air Scientific Advisory Committee Integrated Science Assessment for Sulfur Oxides and a member of the US Department of Energy?s Scientific Review Group of the joint US-Russia Coordinating Group for Human Radiation Effects. Dr. Griffith received his MS and PhD in biostatistics from the University of Washington.

Dr. Hugh A. Barton
Pfizer Inc.

Hugh A. Barton is an associate research fellow with Pfizer, Inc., working on mechanistic modeling of pharmacokinetics and pharmacodynamics. He is a member of the Translational Modeling and Simulation group that is providing scientific oversight of the application of modeling and biomarkers in drug discovery. He specializes in the use of physiologically based pharmacokinetic and mechanistic pharmacodynamic modeling to predict efficacy and address low-dose, interspecies, and interroute extrapolations in estimating safety risks. He was a toxicologist in consulting companies and the US Environmental Protection Agency before joining Pfizer. Dr. Barton is a member of EPA?s Chemical Assessment Advisory Committee. He received his PhD in toxicology from the Massachusetts Institute of Technology.

Dr. Marie E. Vahter
Karolinska Institutet

Marie E. Vahter is professor at the Institute of Environmental Medicine of the Karolinska Institutet in Sweden and head of the institute?s Unit of Metals and Health. Her research interests are in the human health effects and associated mechanisms of arsenic, cadmium, and lead and in factors that influence susceptibility to these metals, such as metabolism, genetic predisposition, and nutrition. Her recent work focuses on early-life metal exposure. She has also been involved in health risk assessments for a variety of metals throughout her career. Dr. Vahter received her PhD in toxicology from the Karolinska Institutet.

Dr. Jay I. Goodman
Michigan State University

Jay I. Goodman is professor in the Department of Pharmacology and Toxicology at Michigan State University. His current research interests are in discerning epigenetic mechanisms underlying carcinogenesis and other chemical-induced toxicities. He is a past president of the Society of Toxicology, and was the recipient of the Society?s 2014 Merit Award. He also was awarded the 2014 International Achievement Award from the International Society of Regulatory Toxicology and Pharmacology. He received his PhD in pharmacology from the University of Michigan, was a postdoctoral fellow at the University of Wisconsin?s McArdle Laboratory for Cancer Research, and is a diplomate of the American Board of Toxicology and a fellow of the Academy of Toxicological Sciences.

Dr. Yu Chen
New York University

Yu Chen is associate professor in the Departments of Population Health, Environmental Medicine, and Medicine at the New York University School of Medicine. Her research focuses on how host and environmental factors are related to the risk of clinical and preclinical end points of cancer and cardiovascular disease. Dr. Chen is the recipient of the Outstanding New Environmental Scientist Award from the National Institute of Environmental Health Sciences to study the interactions between arsenic exposure from drinking water and genetic susceptibility related to inflammation and oxidative stress in cardiovascular disease. She received her MPH in health policy and management and PhD in epidemiology from Columbia University.

Dr. David C. Bellinger
Harvard Medical School

David C. Bellinger is professor in the Department of Environmental Health at the Harvard T.H. Chan School of Public Health. He is also a professor of neurology and of psychology at the Harvard Medical School. His research focuses on factors that influence children?s neurodevelopment, including environmental pollutants (e.g., lead, methylmercury, arsenic), therapeutic interventions (e.g., anesthesia, dental amalgams), and medical conditions (e.g., congenital heart lesions, congenital diaphragmatic hernia). Dr. Bellinger has served on several scientific committees for the US Environmental Protection Agency, the US Food and Drug Administration, and the Centers for Disease Control and Prevention. Service on committees of the National Academies of Sciences, Engineering, and Medicine include membership on the Committee on Nutrient Relationships in Seafood: Selections to Balance Benefits and Risks and the Committee on Toxicological Effects of Mercury. He received his PhD in psychology from Cornell University, and his M.Sc. in epidemiology from the Harvard School of Public Health.

Dr. James A. Swenberg
University of North Carolina, School of Medicine

James A. Swenberg is Kenan Distinguished Professor in the Department of Environmental Sciences and Engineering at the Gillings School of Global Public Health at the University of North Carolina, Chapel Hill. His research interests are in chemical carcinogenesis, with an emphasis on studying the role of DNA damage and repair, developing highly sensitive assay methods for DNA and protein adduct research, and improving the scientific basis of risk assessment. Dr. Swenberg has been an active member of the Society of Toxicology, including service as president of the carcinogenesis specialty section. He was the recipient of the 2007 Merit Award from the society. He received his DVM from the University of Minnesota and his MS and PhD in veterinary pathology from Ohio State University.

Dr. Habibul Ahsan
The University of Chicago

Habibul Ahsan is the Louis Block Professor in the Departments of Public Health (primary), Human Genetics (secondary), and Medicine (secondary) at the University of Chicago. He also holds appointments as director of the Center for Cancer Epidemiology and Prevention, associate director for population research at the university?s Comprehensive Cancer Center, associate director of research at the Center for Global Health, and chief executive officer and chairman on the University of Chicago Research Bangladesh. He studies the relationships between environmental and genomic factors in cancer and other diseases. He has published extensively on the molecular epidemiology and prevention of health effects of arsenic exposure and on the molecular and genetic epidemiology of breast and other cancers. Dr. Ahsan is a member of the National Advisory Environmental Health Sciences Council of the National Institutes of Health and the National Institute for Environmental Health Sciences. He received his MD from Dhaka University and his MMedSc in epidemiology from the University of Western Australia.

Dr. Gary L. Ginsberg
Connecticut Department of Public Health

Gary L. Ginsberg is a senior toxicologist in the Connecticut Department of Public Health Division of Environmental and Occupational Health Assessment. He is involved in the use of toxicology and risk-assessment principles to evaluate human exposures to chemicals in air, water, soil, food, and the workplace. He has published in toxicology, carcinogenesis, physiologically based pharmacokinetic modeling, interindividual variability, and children?s risk assessment. He also holds an adjunct faculty position at the Yale School of Medicine and is an assistant clinical professor at the University of Connecticut School of Medicine. Dr. Ginsberg has served on several committees of the National Academies of Sciences, Engineering and Medicine, including the Committee on Improving Risk Analysis Approaches Used by the US Environmental Protection Agency and the Committee on Human Biomonitoring for Environmental Toxicants. He received his PhD in toxicology from the University of Connecticut.

Dr. Koren K. Mann
McGill University

Koren K. Mann is an assistant professor in the Department of Oncology at McGill University. Her research interests are in the toxicology of metals, specifically arsenic and tungsten. Current research on arsenic is focused on investigating its effects on macrophages and how that affects the development of artherosclerosis. She first linked arsenic exposure to inhibition of nuclear receptors, specifically those that heterodimerize with the retinoid X receptor. Dr. Mann is an active member of the Society of Toxicology, and currently serves as the secretary and treasurer of the Metals Specialty Section. She received her PhD in pathology and immunology from Boston University.

Dr. J. Christopher States
University of Louisville

J. Christopher States is professor in the Department of Pharmacology and Toxicology at the University of Louisville. He is also vice chair for graduate education and associate dean for research. His research interests are in arsenic carcinogenesis, arsenic-induced cardiovascular disease, disruption of mitosis and chemotherapy, and molecular biology and genetics of human DNA repair. He is the editor of Arsenic: Exposure Sciences, Health Risks, and Mechanisms of Toxicity. Dr. States is an active member of the Society of Toxicology, and has served as president of the Metals Specialty Section. He received his PhD in molecular biology and pathology from Albany Medical College, Union University.

Dr. Mark A. Ratner
Northwestern University

Mark A. Ratner is the Lawrence B. Dumas Distinguished University Professor in the Department of Chemistry at Northwestern University. He is a materials chemist, whose work focuses on the interplay between molecular structure and molecular properties. Areas of interest include molecular electronics, molecular optoelectronics, molecular systems design and biomolecular behavior, as well as quantum and classical methodologies for understanding and predicting molecular structure and response. Dr. Ratner was elected to the National Academy of Sciences in 2002 in recognition of his contribution to molecular materials theory and modeling. He received his PhD in chemistry from Northwestern University.

Dr. James S. MacDonald
Chrysalis Pharma Consulting, LLC

James S. MacDonald is founder and president of Chrysalis Pharma Consulting, a firm focused on bringing new molecular entities from the lead optimization stage to proof-of-concept in patients. He is also a founding partner of Synergy Partners R&D Solutions, LLC, which partners with small and medium sized pharmaceutical companies to enable rapid movement of new concepts for breakthrough therapies into human clinical testing, proof-of-concept and partnering to support further development. Over a period of 31 years before founding these companies, he held several leadership positions at Merck and Schering-Plough, retiring as executive vice president of preclinical development. In the latter role, he oversaw the company?s Department of Drug Safety and Department of Drug Metabolism/Pharmacokinetics and led efforts to move new molecular entities from discovery into clinical trials. Dr. MacDonald?s research interests lie in assessing strategies for identifying potential human cancer hazards and in using mode-of-action data in assessing human relevance. He received his PhD in toxicology from the University of Cincinnati and is a diplomate of the American Board of Toxicology.

Dr. Scott W. Burchiel
The University of New Mexico

Scott W. Burchiel is professor and DeSantis Endowed Chair of Pharmacogenomics and associate dean for research at the University of New Mexico. His research interests are in the area of immunopharmacology and immunotoxicology with emphasis on the effects of drugs and environmental agents on signaling pathways controlling lymphocyte activation and apoptosis. A current line of research is studying potential synergistic immunosuppression by polycyclic aromatic hydrocarbons and arsenite in mice and in human cells. Dr. Burchiel was a member of the Committee on Beryllium Alloy Exposures and the Committee for Review of the Health Effects of Vietnam Veterans of Exposure to Herbicides. He received his PhD in pharmacology from the University of California, San Francisco.

Dr. Bhramar Mukherjee
University of Michigan

Bhramar Mukherjee is professor and associate chair of the Department of Biostatistics at the University of Michigan, and is co-director of the Statistics Core for Global Health. She is also a professor in the Department of Epidemiology. Her research interests lie in Bayesian methods in epidemiology and studies of gene-environment interaction. She is also interested in modeling missingness in exposure, categorical data models, Bayesian nonparametrics, and the general area of statistical inference under outcome- or exposure-dependent sampling schemes. Dr. Mukherjee is an elected member of the International Statistical Institute and is a fellow of the American Statistical Association. She has received an outstanding alumna award from Purdue University and the outstanding young statistician award in the area of statistical applications from the International Indian Statistical Association. She received her MStat in applied statistics and data analysis from the Indian Statistical Institute, and her MS and PhD in statistics from Purdue University.

Dr. Ana Navas-Acien
Johns Hopkins Bloomberg School of Public Health

Ana Navas-Acien is associate professor in the Department of Environmental Health Sciences of the Johns Hopkins Bloomberg School of Public Health. She is a physician?epidemiologist with a specialty in preventive medicine and public health. Her research interests are in cardiovascular effects and diabetes related to chronic exposure to arsenic in drinking water and food. She is currently the principal investigator in a large prospective cohort study of arsenic exposure and metabolism in American Indian communities. Other research interests include the cardiometabolic and renal effects of cadmium and lead and characterization of secondhand-smoke exposure in indoor public places. Her work for the National Academies of Sciences, Engineering, and Medicine includes past service on the Committee on Science for EPA?s Future and current service on the Committee on Emerging Science for Environmental Health Decisions. Dr. Navas-Acien received her MD from the University of Granada School of Medicine in Spain, her MPH from the National School of Health in Madrid, and her PhD in epidemiology from the Johns Hopkins University Bloomberg School of Public Health.